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Marijuana has been used to treat pain as far back as 2900 B.C. (2Trusted Source).
More recently, scientists have discovered that certain components of marijuana, including CBD, are responsible for its pain-relieving effects.
The human body contains a specialized system called the endocannabinoid system (ECS), which is involved in regulating a variety of functions including sleep, appetite, pain and immune system response (3Trusted Source).
The body produces endocannabinoids, which are neurotransmitters that bind to cannabinoid receptors in your nervous system.
Studies have shown that CBD may help reduce chronic pain by impacting endocannabinoid receptor activity, reducing inflammation and interacting with neurotransmitters (4Trusted Source).
For example, one study in rats found that CBD injections reduced pain response to surgical incision, while another rat study found that oral CBD treatment significantly reduced sciatic nerve pain and inflammation (5Trusted Source, 6Trusted Source).
Several human studies have found that a combination of CBD and THC is effective in treating pain related to multiple sclerosis and arthritis.
An oral spray called Sativex, which is a combination of THC and CBD, is approved in several countries to treat pain related to multiple sclerosis.
One study of 47 people with multiple sclerosis examined the effects of taking Sativex for one month. The participants experienced improvements in pain, walking, and muscle spasms. Still, the study didn’t include any control group and placebo effects cannot be ruled out (7Trusted Source).
Another study found that Sativex significantly improved pain during movement, pain at rest and sleep quality in 58 people with rheumatoid arthritis (8Trusted Source).
SUMMARYCBD, especially in combination with THC, may be effective in reducing pain associated with diseases like multiple sclerosis and rheumatoid arthritis.
Anxiety and depression are common mental health disorders that can have devastating impacts on health and well-being.
According to the World Health Organization, depression is the single largest contributor to disability worldwide, while anxiety disorders are ranked sixth (9).
Anxiety and depression are usually treated with pharmaceutical drugs, which can cause a number of side effects including drowsiness, agitation, insomnia, sexual dysfunction and headache (10Trusted Source).
What’s more, medications like benzodiazepines can be addictive and may lead to substance abuse (11Trusted Source).
CBD oil has shown promise as a treatment for both depression and anxiety, leading many who live with these disorders to become interested in this natural approach.
In one Brazilian study, 57 men received either oral CBD or a placebo 90 minutes before they underwent a simulated public speaking test. The researchers found that a 300-mg dose of CBD was the most effective at significantly reducing anxiety during the test.
The placebo, a 150-mg dose of CBD, and a 600-mg dose of CBD had little to no effect on anxiety (12Trusted Source).
CBD oil has even been used to safely treat insomnia and anxiety in children with post-traumatic stress disorder (13Trusted Source).
These qualities are linked to CBD’s ability to act on the brain’s receptors for serotonin, a neurotransmitter that regulates mood and social behavior.
SUMMARYUsing CBD has been shown to reduce anxiety and depression in both human and animal studies.
Continue at: https://www.healthline.com/nutrition/cbd-oil-benefits#section2
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