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- BOTOX® is a drug known most widely for its ability to temporarily smooth out facial wrinkles, though it also has several medical applications. Both its cosmetic and medical applications relate to Botox’s ability to block muscle contractions.
- Botox belongs to a class of products known as biologics—physiologically active substances produced naturally by organisms (in this case bacteria) or synthetically in the laboratory
- Botulinum toxin is a neurotoxin protein produced by the bacterium Clostridium botulinum. It is one of the most poisonous naturally occurring substances in the world, and it is the most toxic protein. It is sold commercially under the brand names Botox and Dysport for this purpose. The terms Botox and Dysport are trade names and are not used generically to describe the neurotoxins produced by the clostridia species.
- Botox blocks signals from the nerves to the muscles. The injected muscle can no longer contract, which causes the wrinkles to relax and soften. It is most often used on forehead lines, crow’s feet (lines around the eye) and frown lines. Wrinkles caused by sun damage and gravity will not respond to Botox.
- The market trend for BOTOX® injection rates are up 31%, while alternatives such as chemical peels are down 31%, and collagen injections, once very popular, have dropped by 46%. The consumer can pay $5000 for a facelift to remove lines and wrinkles now, or as an alternative can undertake twelve BOTOX® injections over time.
- Consumers are avid for non-invasive alternatives to Botox and cosmetic surgery, driving a “cosmeceuticals” market destined to grow 8.5% to $5.1 billion by 2007.
- The increase in popularity of nonsurgical procedures like Botox injections for wrinkles is due to people becoming satisfied with less drastic measures to remove wrinkles. From 2002 to 2003, the demand for Botox injections for wrinkles resulted in a 153 percent increase, accounting for more than 887,000 procedures.
- Costs for botox can vary significantly based on how much an individual needs and wishes to get, and based on who is administering it. Some skin care centers advertise low prices for botox on a “cost per area” basis, advertising prices of $200-$300 for one area.
- The first rule of Botox safety is that the procedure is perform only by a board certified plastic surgeon who has experience with all aspects of the Procedure.
- Botox is approved by the U.S. Food and Drug Administration (FDA) to treat several medical conditions (its “therapeutic” applications):
• Cervical Dystonia – involuntary movement and prolonged muscle contraction of the neck, • Blepharospasm – involuntary forcible closure of the eyelids, • Strabismus – crossed eyes, • Hyperhidrosis – excessive sweating, • Dynamic muscle contracture in pediatric cerebral palsy patients (approved as an orphan drug) – an abnormality of motor function usually acquired at a young age.
- Botox has been approved for cosmetic applications in the following countries: Canada (2001), New Zealand (2001), United States (2002), Australia (2002), Switzerland (2002), Taiwan (2002), Singapore (2002), and France.
- Botulinum toxin type A, brand name Botox®, is an effective preventative therapy for headache and Migraine pain in chronic sufferers, according to the largest study performed to date, presented at the 45th Annual Scientific Meeting of the American Headache Society (AHS) in June.
- Botox is approved by the Food and Drug Administration (FDA) for treatment of blepharospasm (eyelid spasm), strabismus (crossed eyes), cervical dystonia (painful neck spasms) and wrinkles between the eyebrows, but not for headache or Migraine. Studies to obtain FDA approval for that use are proceeding
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