Highly pure Cannabidiol (CBD) by twin-column chromatography (MCSGP)

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Cannabidiol (CBD) is under investigation as therapeutic for several indications including pain relief. Recently, the FDA has approved a highly pure CBD formulation (Epidiolex®) for epilepsy. Crude CBD extracts from hemp plants contain a large number of natural products, including tetrahydrocannabinol (THC), a psychoactive component.

Since THC is a controlled substance in most countries, CBD purification must ensure removal of THC down to 100-1000 ppm levels. Traditional preparative purification methods for CBD, like single-column chromatography, can reach such low THC contents only at the expense of CBD yield, wasting a large amount of valuable product. This can be prevented by using a continuous twin-column chromatography process:

Multi-column Counter-current Solvent Gradient Purification (MCSGP) is capable of isolating target compounds with high purity, yield and throughput, significantly outperforming single column chromatography. This application note shows how highly pure CBD with a THC content below 100 ppm was obtained from pre-treated hemp plant extract. The process provided a yield of 95%, an increase of 72% relative to single column batch chromatography.

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Continue at: https://www.chromacon.com/resources/public/lava3/media/kcfinder/files/CBD_MCSGP_application_note.pdf


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