Heating, ventilation and air-conditioning (HVAC) play an important role in ensuring the manufacture of quality pharmaceutical products. A well designed HVAC system will also provide comfortable conditionsfor operators.
These guidelines mainly focus on recommendations for systems for manufacturers of non-sterile dosage forms, and include tablets, capsules, powders, liquids, creams, ointments, etc. The HVAC design principles contained in the guidelines may be applied to other dosage forms.
HVAC system design influences architectural layouts with regard to items such as airlock positions, doorways and lobbies.The architectural components have an effect on room pressure, differential cascades and cross contamination control. The prevention of contamination and cross contamination is an essential design consideration of the HVAC system. In view of these critical aspects, the design of the HVAC system should be considered at the concept design stage of a pharmaceutical manufacturing
Temperature, relative humidity and ventilation should be appropriate and should not adversely affect the quality of pharmaceutical products during their manufacture and storage, or the accurate functioning of equipment.
This document aims to give guidance to pharmaceutical manufacturers.
Continue at: https://www.who.int/medicines/areas/quality_safety/quality_assurance/HVAC_QAS15-639_31082015.pdf
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