Calculating the Contaminant Concentration in Membrane Dialysis




This application simulates the contaminant concentration within a bloodstream that is purified within a membrane dialysis device. The modeled dialysis device is made of a hollow fiber module, where the walls of the hollow fibers act as a membrane for removal of the contaminant. Within the inside of the fibers, the dialysate flows, whereas on the outside, the permeate passes. Through variation of the input parameters, the app can examine approaches on how to maximize the contaminant removal within the device.

The input parameters are the following:
• Inlet contaminant concentration in the dialysate.
• Partition coefficient at the liquid-membrane interfaces.
• Diffusion coefficients of the contaminant in the dialysate, permeate, and membrane.
• Geometry of the model domain.

In the Graphics & Results section, the selected geometry settings and contaminant concentrations are displayed. The concentration at two positions along the fiber, at half fiber length and at the outlet, are shown in detail. The same section shows the computed average concentration at the outlet and the contaminant removal. The image below summarizes how to use the application.


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