FORMULATION DEVELOPMENT AND OPTIMIZATION OF IBUPROFEN TABLETS BY DIRECT COMPRESSION METHOD – PDF Download

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Ibuprofen is a commonly used NSAID (Abraham et al., 2005). Low-dose Ibuprofen is as effective as  spirin and paracetamol for the indications normally treated with over-the-counter (OTC) medications (Moore, 2003).

Ibuprofen is used as an analgesic, anti-inflammatory agent and anti-pyretic agent (Wood et al., 2006). Recemic Ibuprofen and the S (+)-enantiomer are mainly used in the treatment of mild to moderate pain related to dysmenorrhoea, headache, migrane, post operative and in the management of spondylitis, Osteo-arthritis, rheumatoid arthritis, and soft tissue disorders (Potthast, 2005 and Tan et al., 1999). Ibuprofen also studied for the closure of the ductus arteriosus.

Results indicate that Ibuprofen is as effective as Indomethacin (Kravs and Pharm, 2005). Dental practitioners have relied on Ibuprofen and other nonsteroidal anti-inflammatory drugs to manage acute and chronic orofacial pain (Moore and Hersh, 2001).

The common analgesic drug Ibuprofen (C13H18O2) shows bad dissolution and tableting behavior due to its hydrophobic structure. Additionally its high cohesivity results in low flowability. Another problem in its manufacturing is its high tendency of sticking to the punches (Rasenack and Muller, 2002).

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